The differential expression of commercial PD-L1 antibodies is well known but poorly understood. Our epitope mapping of four antibodies reveal that antigen binding might be depending on PD-L1 conformation or isoform expression. For example, the presence of the dominant isoform 2 may impact SP142 binding. 

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HistoGeneX’s Founder and Head Pathologist, Mark Kockx is interviewed by CAP Today for his histopathology perspectives of inflammation within the tumor microenvironment.

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