Epitope Mapping of PD-L1 Primary Antibodies

The differential expression of commercial PD-L1 antibodies is well known but poorly understood. Our epitope mapping of four antibodies reveal that antigen binding might be depending on PD-L1 conformation or isoform expression. For example, the presence of the dominant isoform 2 may impact SP142 binding. 

ImmTherPoster2017